Noel Caplice CSO & Co-Founder Mayo Clinic Trained Interventional Cardiologist PhD Vascular Biologist with 30 years Physician Scientist experience Serial inventor with first in man clinical trial experience Dr
Common side effects include pain or redness at the injection site, mild diarrhea, itching, and swelling
Always consult with a licensed healthcare provider
Too much vitamin B12 may also cause or exacerbate acne Vitamin B12 is a "water-soluble vitamin," according to Rachel Feaster, PharmD (via GoodRX)
A: Side effects are rare but may include pain at the injection site and, in cases of overdose, hypercalcemia (elevated blood calcium levels)
From a laboratory medicine perspective, the Association for Clinical Biochemistry and Laboratory Medicine (ACB) and the Royal College of Pathologists (RCPath) advise that: HbA1c may be unreliable in the presence of haemolytic anaemia, haemoglobinopathies, or nutritional deficiencies affecting red cell biology and the direction of distortion may be high or low Clinicians should document any known haematological conditions when requesting HbA1c, so laboratory staff can flag potential inaccuracies Serum B12 testing should be considered in patients on long-term metformin who are symptomatic or have risk factors for deficiency, in line with MHRA and NICE advice Alternative tests fasting plasma glucose, OGTT, or interim use of fructosamine/glycated albumin should be considered when HbA1c reliability is in doubt The NHS website (nhs.uk) provides patient-facing information on the HbA1c test and factors that can affect its accuracy, which patients may find a useful starting point
