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In mice, the bulk of the metabolic improvement seen upon FGF21 treatment derives from centrally mediated weight loss, whereas FGF21 analogs elicit limited weight loss in humans

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Potential Side Effects PT-141 may cause side effects

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Circulating IGF-1 deficiency exacerbates hypertension-induced microvascular rarefaction in the mouse hippocampus and retrosplenial cortex: implications for cerebromicrovascular and brain aging