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Frontiers in Medicine, 10

These also present opportunities for antifungal drug target development

Irrefutable evidence from over 30 years ago showed that maternal folic acid supplementation in early pregnancy could protect against NTD (80,Reference Czeizel and Duds81) , leading to global recommendations for supplementation of women with folic acid at 400 g/d from preconception to the end of the first pregnancy trimester

Additionally, studies in rotenone-induced PD models demonstrated that microglial complement receptor 3 (CR3) activates NADPH oxidase 2 (NOX2), leading to ROS production

The resulting cysteine is unstable at extracellular level, and it is rapidly autoxidizes to cystine