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Secondhand smoke can also contribute to the development of chronic bronchitis

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Genetic variants interact with medications as well as other substances (such as caffeine) that are metabolized by the same enzyme.[ref] For example, someone with a slow CYP1A2 genotype may find that taking an inhibitor of CYP1A2 at the same time as drinking a caffeinated beverage causes the caffeine to remain in their system longer