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Simultaneously, the activation of the PI3K/Akt pathway leads to the phosphorylation and activation of endothelial Nitric Oxide Synthase (eNOS)

Patients who have an ischemic stroke in the morning, or onset of their active period, are not only at a greater risk for poor outcome based on the hyperfibrinolytic morning state, but additionally, response to thrombolytic intervention is less efficacious during the morning time points

10.1016/j.cardiores.2007.03.022 13 BryanN

Autonomic nervous system dysfunction in adolescents with postural orthostatic tachycardia syndrome and chronic fatigue syndrome is characterised by attenuated vagal baroreflex and potentiated sympathetic vasomotion

111127 Ursini F, Heim S, Kiess M, Maiorino M, Roveri A, Wissing J et al (1999) Dual function of the selenoprotein PHGPx during sperm maturation