New basic and clinical research is clarifying the mechanistic relevance and therapeutic feasibility of multiple targets within the glutamate system for novel drug discovery, including NMDA and AMPA (-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid) receptors, metabotropic glutamate receptors, and other key regulatory proteins such as glycine transporter 1 and excitatory amino acid transporters
Statistical analysis All graphs and statistics were performed using GraphPad prism version 6
Exp Anim Tokyo
The apparent V max for various concentrations of inhibitors were used to calculate K i values
Shults CW, Oakes D, Kieburtz K, Beal MF, Haas R, Plumb S, Juncos JL, Nutt J, Shoulson I, Carter J et al (2002) Effects of coenzyme Q10 in early Parkinson disease: evidence of slowing of the functional decline
Stroes, E