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The significance of specific microbial shifts, such as an increased Firmicutes / Bacteroidetes ratio, extends beyond a mere descriptive biomarker

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Hyperpigmentation is mainly caused by an overproduction of melanin in a particular area of the skin

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DNA methylation, particularly in CpG islands, regulates gene expression, with hypomethylation in synovial fibroblasts and peripheral blood mononuclear cells (PBMCs) contributing to inflammation and joint damage

Optimization of the hemolysis assay for the assessment of cytotoxicity