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Some transporters that allow melatonin to cross the cell membrane into the cytosol are the glucose transporters (GLUT-1) and oligopeptide transporters (PepT 1 and 2)

Endothelial cells: Rich VEGF receptor expression (VEGFR1, VEGFR2) makes them primary angiogenesis targets

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Subsequent mass spectrometry analysis identified interacting proteins, with AFG3-like matrix AAA peptidase subunit 2 (AFG3L2), a mitochondrial inner membrane m-AAA protease, highlighted as a key interactor