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Insect herbivory and physical damage to the plant can increase nicotine accumulation

Many smokers notice an increased tightness in the chest, mucus and a developing cough

Alcohol consumption is associated with the development of cancers of the oral cavity, oropharynx, hypopharynx, esophagus (squamous cell carcinoma), colon, rectum, liver, intrahepatic bile duct, larynx, and female breast

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