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HSCs contain approximately 50-80% of the whole body stores of retinoids (Blomhoff et al., 1990)

This limits their capacity to represent the etiology of human obesity, insulin resistance, and hepatic steatosis

The 2.5 mg starting dose exists purely for gastrointestinal tolerance, not for metabolic effect

It is a naturally occurring peptide that originates from a protein found in the stomach & has been modified to improve its stability & bioavailability

Those with conditions like IBS, IBD, gastritis, or ulcers often use oral protocols with doses of 0.5 to 1 mg daily to maximize local gastrointestinal exposure

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