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Some autoimmune diseases can affect B12 metabolism or produce antibodies that interfere with B12 assays, potentially leading to falsely elevated readings

Continuous forever is the single option the evidence actively cant back, and the convenience gained from it doesnt come close to justifying the unknowns it takes on

However, the review emphasized that the majority of studies utilized small rodent models, and efficacy in humans remains to be confirmed through adequately powered clinical trials