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however, this enzyme was mutated in hominoids five to fifteen million years ago.[1] This loss of uricase activity not only results in higher plasma UA levels, but also limits our ability to regulate UA, such that widely varied levels may be observed in man

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To induce PCOS, the rats were administered dehydroepiandrosterone (DHEA) (Sigma, 6 mg/100 g body weight dissolved in 0.2 ml sesame oil) via subcutaneous injection for 21 consecutive days 24,53,54

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6eg), glucose tolerance (Fig