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Wolffenbuttel BHR, Muller Kobold AC, SobczyskaMalefora A, Harrington DJ

N-acetylcysteine protects human periodontal ligament fibroblasts from pyroptosis and osteogenic differentiation dysfunction through the SIRT1/NF-B/Caspase-1 signaling pathway

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In summary, a large body of research evidence shows that FA synergizes with MSU crystals to induce the initiation of inflammation in GA: FA induces macrophage activation by activating TLR receptors, lysosomal instability/NLRP3, and AMPK/ROS/NLRP3 pathways, while more active FAO promotes the conversion of macrophages to a pro-inflammatory phenotype ( Figure 2 )

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