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Moore and Tabas 2011)

They are also the inspiration behind many therapeutic peptide drugs

Acknowledgements We appreciate the support from the National Natural Science Foundation of China (82071676, 81703492)

First, insulin resistance has been observed without decreased phosphorylation of Akt at its activating phosphosites in diverse models of insulin-resistant 3T3-L1 adipocytes and L6 myotubes, and human muscle ex vivo and in vivo [2329]

2015;112:E4600E4609

This transporter selectively accumulates glutamate through a sodium-independent, ATP-dependent process (Naito and Ueda, 1983, Tabb and Ueda, 1991, Fykse and Fonnum, 1996), resulting in a high concentration of glutamate in each vesicle