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It can cause permanent neurological changes or fatigue

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For instance, it remains undefined whether PKD1/PKD2 loss-of-function directly modulates the transcription or stability of ferroptosis regulators (e.g., SLC7A11, GPX4, and TFR1) or indirectly via downstream signaling cascades (e.g., cAMP/PKA and mTOR, which are known to be dysregulated in ADPKD)

Without these proteins, the bacteria can't multiply and eventually die off, which helps your body overcome the infection