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Make sure you're hitting adequate protein and nutrients - the appetite suppression from semaglutide can make it easy to under-eat protein

In addition to its role in energy metabolism, NAD+ is also involved in DNA repair and cell signaling

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NAD+ supports metabolism, DNA repair, cell defenses, circadian rhythm coordination and other cellular processes which leads to better quality of life

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and a 2021 peer-reviewed review on NNMT in obesity and type 2 diabetes noting the absence of human clinical trials