Continue protocol through initial period allowing adequate exposure time
Extraction techniques were reported to influence the quantity of active substances and the diversity of minor compounds, which resulted in differences in the pharmacokinetic parameters
Both have good safety profiles
The animal study (protocol# wydw2023-0484) was approved by the Institutional Animal Care and Use Committee of Wenzhou Medical University and conducted in compliance with relevant local guidelines and regulations
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doi: 10.1016/j.jep.2016.05.010
