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Clinical trials consistently show measurable reduction in hyperpigmentation at concentrations of 14%, with results appearing over six to twelve weeks of consistent use

Long-term Use : Prolonged use beyond a few months should be approached with caution

[1] [2] This occurs because B12 deficiency commonly affects the peripheral nerves, particularly those extending to the extremities

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Initial adjustment symptoms like mild redness and tingling often improve within days of reducing application frequency

Given its uniqueness, the Hv1 channel has become an attractive and specific target, which is expected to realize precision therapy for neurological diseases