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It is a nicotine analog, not the absence of nicotine

Loss of S100A9 (MRP14) results in reduced interleukin-8-induced CD11b surface expression, a polarized microfilament system, and diminished responsiveness to chemoattractants in vitro

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17% of White Other ethnicity pupils were current smokers compared to 6% of mixed ethnicity pupils

She broke it all down in The Conversation