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Clinical Complications Though MTHFR deficiency can directly cause the above signs and symptoms, it can also worsen the impact of other conditions, including: Various forms of cancer, including breast, rectal, gastric, and prostate Dementia Neurological disorders Congenital heart defects Diabetes Glaucoma Different types of polymorphism Nine polymorphisms, or common variants, of the MTHFR gene have been identified

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