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The 1 mg dose has direct human diabetes-trial activity. Below 1 mg is more speculative

Vit B12 and synucleinopathy A recent study demonstrated that Vit B12 effectively impedes the formation of SN fibrils in a manner dependent on dosage in-vitro experiments

However, results can vary depending on the horses condition and dosage

They may develop a loss of energy and appetite and failure to thrive, which if not treated on time can lead to coma and death

In contrast, the passive diffusion process of B 12 absorption normally a very small portion of total absorption of the vitamin from food consumption may exceed the haptocorrin- and IF-mediated absorption when oral doses of B 12 are very large, with roughly 1% efficiency

For weight loss, the effects are typically seen over time, especially when combined with a healthy diet and exercise routine