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BMC Gastroenterol 20:13 Choi SB, Lew LC, Yeo SK, Nair Parvathy S, Liong MT (2015) Probiotics and the BSH-related cholesterol lowering mechanism: a Jekyll and Hyde scenario

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The mast cells activated by various stimulants such as phorbol 12myristate 13acetate (PMA) and calcium ionophore A23187 (PMACI) activated a signaling cascade, culminating in JNK phosphorylation, activating AP-1 (c-Jun/c-Fos), which is essential for the expression of many pro-inflammatory cytokine-encoding genes, such as tumor necrosis factor- (TNF-), interleukin-6 (IL-6), and thymic stromal lymphopoietin (TSLP) ( While caudatin shares mechanistic similarities with compounds such as sulforaphane when modulating downstream NF-B activation, the ability of caudatin to specifically inhibit AP-1 signaling presents a new therapeutic opportunity

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Gentle swirling or patient waiting is always the correct approach

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