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doi: 10.1016/j.actbio.2022.08.054 97

Studies have shown that ginsenosides induce ferroptosis in HT-29 and HCT116 CRC cells through activation of the ROS/P53 pathway 12

Therefore, these metabolites unambiguously indicate the presence of P

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PHASE II DRUG METABOLISM: Glucuronidation and SulfationGeneral properties of Phase II metabolismIntroduction to glucuronidationSubstrates for UGTsUGT structureProperties of glucuronidesMethods to characterize glucuronidesDisposition and reactions of glucuronidesUGT pharmacogenetics, polymorphism, variabilitySulfotransferasesN-Acetylation, Aminoacid conjugation, Glutathione conjugationSmith, Phase II Metabolism, UNC Chapel Hill, 8/2012 1 Conjugation Reactions Some DefinitionsGlucuronidation conjugation is the addition of a molecule to the drug or xenobioticGSH conjugation GSH = glutathione (a tripeptide derivative)Sulfate conjugationAmino acid conjugation Some confusing terminology, both related to drugs:Acetylation Phase 1, Phase 2, Phase 3 are designations used in theMethylation sequence of drug development and evaluation by FDA in the US

A lipotropic injection typically includes vitamin B12, methionine, inositol, and choline