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In some embodiments, local otic delivery of the auris formulations or compositions described herein allows for controlled release of active agents to auris structures and overcomes the drawbacks associated with systemic administration (e.g., low bioavailability of the drug in the endolymph or perilymph, variability in concentration of the drug in the external, middle and/or internal ear)

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In addition to such clinical trials, there is a literature of their use in humans for up to a year or more, including children, without a single report of toxicity

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The safest response is to raise it with your GP or haematologist, who can look at your schedule, your dose and your original results together