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Zhang J, Jia P-P, Liu Q-L, Cong M-H, Gao Y, Shi H-P, et al

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Also, the male KO mice had an increased CYP1A2 (Part of the P450 enzyme family that are responsible for a large part of detoxification), however this wouldnt really explain the differences seen in Figure 2 (side-note: Ok, this last part was extremely geeky and I try to make this as mainstream as possible

Several factors can cause or contribute to the development of MCAS, including the following: Here at BioDesign Wellness Center, were seeing a strong connection between patients with MCAS and environmentally acquired illness (EAI) typically from water-damaged buildings and the subsequent exposure to mold toxins, microorganisms, and volatile organic compounds (VOCs)

That is a plausible site-targeting strategy