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The capsule formulation offers researchers advantages over powder form including reduced exposure risk, better handling characteristics and more consistent experimental parameters

The dominant driver is reduced caloric intake

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Im not sure whether I can buy smaller doses of B12 vials but will have to have a look as this would be easier

Taken together, all these issues make less weight loss an expected finding in SELECT, compared with STEP 1

In the STEP 1 trial, semaglutide led to an average 14.9% reduction in body weight over 68 weeks , far outperforming placebo (NEJM study on semaglutide for weight loss)