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Consequently, the suggested combination approach holds the promise of enabling the use of lower doses of conventional chemotherapy, thereby mitigating undesirable toxic effects

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Compared with existing topical therapeutics such as corticosteroids or biological agents, this system offers more precise treatment localization and a more comprehensive therapeutic mechanism, presenting potential as a non-hormonal alternative capable of reducing drug resistance and dependency

More recently, we also evidenced that starvation induced p38 MAPK activation, which by reprogramming glucose metabolism by the pentose phosphate pathway sustains NADPH production