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This is because the pressure inside the stomach and small intestine force the alcohol to be absorbed more quickly into the bloodstream

Future studies demonstrated that KEAP1 does not passively sequester NRF2 in the cytosol, but actively functions as a ubiquitin ligase, leading to ubiquitination and proteasomal degradation of NRF2 (Zhang and Hannink, 2003)

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Cells (2019) 8(8):884