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Additional information Peer review information Nature Communications thanks Lizeng Gaoand the other anonymous reviewer(s) for their contribution to the peer review of this work

B-cell: B lymphocytes are distinguished by the presence of the B-cell receptor (BCR) on their membrane, which is physiologically responsible for recognizing pathogens and producing specific antibodies ( DN2 B-cell: DN2 cells, characterized by the absence of CD27, IgD, and CXCR5 expression but the presence of CD11c, are expanded in SLE patients with severe disease, including nephritis and hyperresponsiveness to TLR7 signaling, which leads to plasmablast differentiation and autoantibody production

The entire body composition evidence base comes from preclinical mouse studies and cell culture experiments

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