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A randomized phase II clinical trial showed that this antibody in combination with epirubicin, cisplatin, and capecitabine (ECX) could prolong PFS in advanced gastric cancer patients relative to the control group, especially in patients with high c-Met expression ( Onartuzumab is a recombinant humanized anti-c-Met monoclonal antibody, which is produced in Escherichia coli (Shah et al., 2016)