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Community sources and pharmacy references describe Hospira as the benchmark because of two attributes that the formula itself does not differentiate: supply chain traceability (every vial is traceable from manufacturing through distribution to end user) and regulatory accountability (FDA-registered facilities are subject to inspection and enforcement)

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Repeated overdoses can also occur with self-harm intent (often termed staggered overdoses), and similarly carry an increased risk of hepatotoxicity when compared to acute self-harm overdoses *