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Serum cotinine measurement employed either isotope dilution-high performance liquid chromatography or atmospheric pressure chemical ionization tandem mass spectrometry 25

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Although such lesions may not as yet have sufficient characteristics to qualify as neoplasms, their recognition has led many to regard them as preneoplastic. According to the multistage model of carcinogenesis, there is a morphological continuum from hyperplasia/preneoplasia to adenoma and carcinoma, which is reflected in the pattern observed in tumor types

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