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Firas Jafri, Gyuhee Seong, and Tim Jang are equal first authors

During this stage, also known as conjugation, molecules combine with the metabolites from the initial phase of detoxification

Although the steady state concentration of superoxide is approximately 5- to 10-fold higher in the mitochondrial matrix than in the cytosol and the nucleus [29], the steady state concentrations of mitochondrial superoxide and H 2 O 2 are estimated to be as low as about 10 10 M and 10 9 ~10 8 M, respectively [27,29]

These data support the rationale that tumors with elevated GST expression are more sensitive to the cytotoxic effects of TLK286