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Safety Profile: What Clinical Trials Actually Documented Across six clinical trials involving approximately 900 participants, AOD-9604 produced no treatment-related serious adverse events, no immunogenic response, no IGF-1 elevation, and no adverse cardiovascular or metabolic signals

Mitochondrial damage caused by ROS not only depletes cellular energy but also creates a vicious cycle of further ROS production, exacerbating the death of endothelial cells [176,183]

Silencing of GLS and overexpression of GLS2 genes cooperate in decreasing the proliferation and viability of glioblastoma cells