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11 When intracellular cholesterol is excessive, it leads to the formation of specific sterols, thereby activating the liver X receptor (LXR)-retinoid X receptor (RXR) heterodimeric transcription factor, which promotes cholesterol efflux from cells by upregulating the expression of ABCA1 and ABCG1

doi: 10.1016/j.yfrne.2010.03.003 Plkki, M

It remains uncertain whether distinct initiation mechanisms trigger the inflammatory response by acting on priming signaling pathways, or if a reduction in the negative regulation of NLRP3 activation amplifies the inflammatory cascade