Although speculative, it is possible that A 142 aggregation is enhanced in the acidic lysosomes due to the high concentration of copper required for antimicrobial activity via copper induced ROS formation from lysosomal H 2 O 2 (Schtzmann et al., 2021
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A relative decrease in aconitase activity in the autism cerebellum is an important new finding, suggesting a functional consequence of oxidative stress in this region