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The REDEFINE clinical trial program has established that: Cagrilintide 2.4 mg + Semaglutide 2.4 mg weekly produces superior weight loss compared to either agent alone The combination achieved 22.7% mean weight reduction at 68 weeks Side effect profiles were manageable with proper dose escalation The amylin + GLP-1 agonist combination demonstrated synergistic effects This validated combination demonstrates that pairing cagrilintide with incretin-based therapies can work effectively