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Efficacy of inflammation-based stratification for add-on celecoxib or minocycline in major depressive disorder: protocol of the INSTA-MD double-blind placebo-controlled randomised clinical trial

Matts PJ et al

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Iron overload increases ferritin levels and decreases RUNX2 levels in BMSCs, causing irregular morphological changes, significantly reducing their activity, and inhibiting osteogenic differentiation, while melatonin therapy could reverse this process and promote osteogenic differentiation of BMSCs

This article reviews the roles of immune cells, GM, and their metabolites in NAFLD development, while exploring the targets and/or pathways through which botanical drugs and their metabolites modulate GM and hepatic immune responses

This distinction fundamentally shapes its pharmacokinetic profile, granting it properties (oral bioavailability, protease resistance, BBB penetration) that most neuropeptides lack