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The current analysis demonstrates the importance of continuous learning through external model validation and the re-estimation process of PK parameters ( Although the implementation of the model-informed precision dosing platform significantly improved clinical target attainment for patients receiving busulfan, limitations remain

J Neuroinflamm (2014) 11:59

In our model we use a V max of 1100 M/hr, a K m of 3000 M, and a Hill coefficient of 3