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It tends to affect men after age 40 and women after menopause, when they lose the protective effects of estrogen

doi: 10.3389/fendo.2023.1271521 Received 02 August 2023 Accepted 17 November 2023 Published 30 November 2023 Volume 14 - 2023 Edited by Ashu Johri, Independent Researcher, New York, NY, United States Reviewed by Shubhadeep Roychoudhury, Assam University, India

The other one we talked about was the Atlantic

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Its all so integrated

HIF-1 forms a heterodimer with HIF-1 in the cytoplasm, translocates into the nucleus, and binds specific HREs on DNA, where it acts as a transcription factor for the downstream target gene VEGF ( Figure 3E )