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This enhancement of testosterone-to-estradiol conversion disrupts the androgen-to-estrogen balance essential for normal male reproductive function ( 3.2.2 Detoxification pathway impairment 3.2.2.1 Cytochrome P450 system dysfunction EED exposure creates a dual dysfunction within the cytochrome P450 system
The paracrine activation of GABA A receptors on NSC populations by their progeny has been shown to have a non-synaptic inhibitory effect on proliferation and likely function as a negative feedback mechanism to modulated proliferation in adult and post-natal brains [120, 121]
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