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Another intriguing approach is using microbial metabolites as adjuncts: as mentioned, oral propionate supplementation led to fewer relapses and increased Tregs in a cohort of MS patients [206]

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154,155,156,157 Currently, the CRISPR/Cas9 system can enter cells for gene editing in three forms: the Cas9: sgRNA ribonucleoprotein complex, mRNA for Cas9 translation alongside a separate sgRNA, and a DNA plasmid that encodes both the Cas9 protein and sgRNA

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