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ARS is also an effective antioxidant (116), which is able to inhibit the production of ROS in osteoclast precursor cells and maintain oxidative homeostasis, thereby inhibiting osteoclastogenesis, by activating p62/Nrf2 signaling pathway and inhibiting NFATc1 signaling

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Studies with exogenous GSSG supplementation have documented that GSSG exposure is associated with apoptosis induction involving the p38 mitogen-activated protein kinase pathway 35

The incidence of CRC was inversely associated with vitamin B6 intake and blood PLP levels (131)

Invasive diagnostics methods includes endoscopic examination, histopathology, rapid urease test (RUT)