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Dosage levels: High doses can lead to headaches or nausea

PMID: 11713213 View source Stier H, et al

Dosage and Administration: For Cattle, Horses, Swine, and Sheep: Cattle and Horses: 10 - 25 mL Calves and Foals: 5 - 12 mL Swine: 2.5 - 10 mL per animal Piglets, Lambs, and Kids: 1 - 2.5 mL For Dogs and Cats: Dogs: 0.5 - 5 mL Cats: 0.5 - 2.5 mL Precautions: 1.Use caution when administering to pregnant or lactating animals

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It was not until a genetically engineered strain of Pseudomonas denitrificans was used, in which eight of the genes involved in the biosynthesis of the vitamin had been overexpressed, that the complete sequence of methylation and other steps could be determined, thus fully establishing all the intermediates in the pathway