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The theoretical advantage is smoother blood levels with less peak-to-trough variation, which may reduce the intensity of side effects, particularly nausea and appetite fluctuation

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A pre-bed dose is timed to reinforce that natural nocturnal pulse, which is why the pre-bed slot is the one most consistently kept even in a once-daily schedule

Given the nervous systems high dependence on continuous energy supply and redox homeostasis, it is exceptionally sensitive to disturbances in riboflavin uptake, metabolism, and utilization