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Antioxidants are adjunctive to medical therapy Oral antioxidants include vitamin B, C, polypodium, glutathione & melatonin Topical antioxidants include vitamin B, C, E, & ferulic acid Oral antioxidants are easier to use for most patients Topical antioxidants can be considered in some patients Skin irritation is the most common side effect of topical antioxidants, esp

When the cell has limited availability of nutrients, as in the case of caloric restriction, mTOR initiates mitophagy

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