Of interest, IGF-IR mRNA is temporally consistent with the IGF-I expression, except from the mural granulose cells, where IGF-IR production is preserved, suggesting a paracrine/endocrine dependence for the IGF-I effects at this level[101]
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This trend is largely driven by nutritional transition, including increased intake of ultra-processed foods and reduced physical activity (Mialon et al., 2021)
2024;10:e24602
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