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Recent findings indicate that rifaximin significantly enhances objective sleep architecture, notably increasing REM sleep, after a 28-day treatment course as evidenced by 24-h polysomnography, although it did not alter subjective perceptions of sleep quality and sleepiness (31, 33)

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47 Heme oxygenase 1 (HO-1) is an iron-dependent antioxidant enzyme, with its expression and activity upregulated by Nrf2

[DOI] [PubMed] [Google Scholar] 114.Pavlov K.A., Chistiakov D.A., Chekhonin V.P