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Under oxidative stress and induced by excessive ROS generation, Nrf2 is released from its inhibitor Keap1, allowing its translocation into the nucleus (Kasprzak et al., 2020), where it binds to the antioxidant response element (ARE) present in the DNA sequence of numerous antioxidant enzymes like glutathione-S-transferase, -glutamyl cysteine synthetase (glutamate cysteine ligase), heme oxygenase 1, and paraoxonase-1 inducing their transcription, managing the phase II response to oxidative stress (Kasprzak et al., 2020)

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Glutathione is your body's master antioxidant produced naturally in every cell to neutralize free radicals, support liver detoxification, recycle other antioxidants like vitamin C and E, and maintain the cellular redox balance that hard training consistently disrupts

Glutathione is your body's most abundant and powerful antioxidant, often called the master antioxidant because it protects every cell in your body

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