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Carotenoids, including astaxanthin, are not automatically released from the cells, thus increased accumulation of astaxanthin in the cells can induce toxicity (Lee et al., 2016)

(PubMed) Traber MG

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Remodeling the tumor microenvironment with core-shell nanosensitizer featuring dual-modal imaging and multimodal therapy for breast cancer

They are designed to dissolve slowly under the tongue, allowing for the medication to be absorbed through the oral mucosa directly into the bloodstream for systemic benefits or for local effects in the oral cavity

It usually doesn't happen all at once